OSTHOLE

Osthole is a coumarin derivative that has shown promising anticancer effects against multiple types of cancer, including breast, lung, hepatic, prostate, and ovarian cancer:  

• Mechanism of action Osthole can inhibit cancer cell growth by inducing apoptosis, inhibiting cellular proliferation, and reversing multidrug resistance. It can also inhibit cancer cell invasion and migration.  

• Effects on specific cancers Osthole has been shown to:

• Inhibit breast cancer: Osthole can target heterogenous cancer cells and multiple signaling pathways in breast cancer. It can also inhibit the migration, invasion, and EMT of breast cancer cells.  

• Regulate autophagy pathway in ovarian carcinoma: Osthole can regulate the autophagy pathway and ER-mitochondrial axis in ovarian carcinoma, leading to apoptotic cell death. 

• Suppress bone loss in breast cancer: Osthole can suppress bone loss and promote bone healing in breast cancer.  

• Other effects Osthole has also been shown to inhibit allergies, inflammation, HIV activity, and diabetes. It can also improve learning and memory.  

Osthole is derived from medicinal plants such as Cnidium monnieri and Angelica archangelica.